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Cancer is the leading cause of death in developed countries. There are over 5 million new cancer cases and 3 million cancer deaths annually in the United States alone. Cancer is caused by a combination of genetic and environmental factors. Ionizing radiation and chemicals, such as polycyclic aromatic hydrocarbons, have been used for decades to study the molecular and cellular mechanisms of DNA damage and repair. The DNA damage response pathway is a highly conserved signaling cascade that is involved in the response to DNA damage. Failure to detect and respond to DNA damage can have disastrous consequences for the cell, as well as an organism. Recent advances in the field of DNA repair have increased our understanding of the potential contribution of DNA damage repair in tumor development. In addition, the current knowledge of the involvement of DNA repair in infectious diseases and chronic inflammatory conditions has expanded. This review focuses on the mechanisms involved in DNA damage response, the role of DNA damage in pathogenesis of chronic inflammatory disease and in cancer, and the potential role of DNA damage repair in the development of inflammatory disease and cancer.Lilly, Queensland
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